OXIDATIVE AND EXCITATORY NEUROTOXIC STRESSES IN CRISPR/CAS9-INDUCED KYNURENINE AMINOTRANSFERASE KNOCKOUT MICE: A NOVEL MODEL FOR DESPAIR-BASED DEPRESSION AND POST-TRAUMATIC STRESS DISORDER

Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder

Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked to disruptions in serotonin (5-HT) metabolism.Over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, which generates a variety of bioactive molecule

read more

The Second Karabakh War and the Dynamics of Relations Between the Republic of Armenia and the Russian Federation

The article examines the dynamics of development of relations between Armenia and Russia after the Second Karabakh War.Armenian-Russian relations are considered in the context of a comparative analysis of regional processes.In the context of the cooling of the Internet Log Book Nagorno-Karabakh conflict, Russia managed to implement a key policy of

read more

Generation of Individualized Synthetic Data for Augmentation of the Type 1 Diabetes Data Sets Using Deep Learning Models

In this paper, we present a methodology based on generative adversarial network architecture to generate synthetic data sets with the intention of augmenting continuous glucose monitor data from individual patients.We use these synthetic data with the aim of improving the Whips overall performance of prediction models based on machine learning tech

read more

SERVICES AND REGIONAL DEVELOPMENT

The purpose of this contribution is to discuss what roles the different economic sectors, and in particular services activities (the tertiary sector) play in regional develop ment, understood as growth in production, incomes and employment in weakly developed regions.This question is approached in two ways.The contribution first contains a - primar

read more